Antioxidant Evaluation of Facial Toner Formulations Containing Ethyl Acetate Fraction from Garcinia Mangostana L. Fruit using ABTS 2,2'-Azinobis 3-ethyl benzothiazoline 6-sulphonic Acid Method

Sriyanty Sadsyam; Nielma Auliah; Wa Ode Wisna Anto Uko; Nasrawati Basir; Andi Ulfiana Utari

doi:10.56741/hesmed.v2i02.266

Authors

Sriyanty Sadsyam
Sriyantisadsyam@unimerz.ac.id
Universitas Megarezky
Nielma Auliah Universitas Megarezky
Wa Ode Wisna Anto Uko Universitas Megarezky
Nasrawati Basir Universitas Megarezky
Andi Ulfiana Utari Universitas Megarezky

DOI:

https://doi.org/10.56741/hesmed.v2i02.266

Keywords:

ABTS, antioxidants, ethyl acetate fraction, mangosteen rind, toner

Abstract

The mangosteen fruit is rich in polyphenols, particularly xanthones, which have potent antioxidant effects. Given the various effects of facial toners and the growing demand for natural skincare products, mangosteen rind may serve as an alternative ingredient in facial toner formulations. This laboratory experimental study aimed to assess the antioxidant activity of facial toner preparations containing the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) using the ABTS method at different concentrations (0.2%, 0.4%, and 0.6%). Four facial toner formulas were formulated, with Formula 1 being the control formula without any active substance and Formulas 2-4 containing the ethyl acetate fraction of mangosteen rind at different concentrations. The prepared formulas underwent physical and chemical stability tests, including organoleptic, homogeneity, pH, viscosity, and humidity tests, before and after six cycles of cycling. The antioxidant activity of the formulas was also evaluated using the ABTS method. The results showed no significant difference (p>0.05) in the organoleptic, viscosity, pH, and humidity tests before and after cycling. Formula 3 showed significant (p<0.05) antioxidant activity compared to the other formulas. Therefore, it can be concluded that the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) can be formulated into a facial toner with potent antioxidant activity.

Downloads

Download data is not yet available.

Author Biographies

Sriyanty Sadsyam, Universitas Megarezky

is an educational scientist and a lecturer in the Pharmacy Study Program at the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She earned her Bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her Master's degree from Universitas Hasanuddin, Indonesia. Her research interests lie in post-incidence therapy, and she is active in various professional associations. (email: sriyantisadsyam@unimerz.ac.id).

Nielma Auliah, Universitas Megarezky

is a dedicated lecturer at the Pharmacy Department of the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She completed her Bachelor's degree at Universitas Hasanuddin Makassar and continued her academic journey by pursuing a Master's degree at the same university. She is particularly interested in drug development and has conducted extensive research on the topic. Her expertise in the field has earned her respect among her colleagues and students alike. (email: nielmaauliah@gmail.com).

Wa Ode Wisna Anto Uko, Universitas Megarezky

is a dedicated student in the Pharmacy Study Program at the Faculty of Pharmacy, Megarezky University Makassar, which is located on Jalan Antang Raya No.4 in Makassar, Indonesia. She is passionate about expanding her knowledge of the field of pharmacy and is committed to using her education to make a positive impact on her community. (email: Wisnauko@gmail.com).

Nasrawati Basir, Universitas Megarezky

is a lecturer at the Pharmacy Department, Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She earned her Bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her Master's degree from Universitas Hasanuddin Makassar, Indonesia. With her expertise in pharmacy, she is committed to promoting excellence in education and research in the field of pharmacy. (email: nasrawatibasir@unimerz.ac.id).

Andi Ulfiana Utari, Universitas Megarezky

is a lecturer in the Pharmacy Department at the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She obtained her bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her master's degree from Universitas Hasanuddin Makassar, Indonesia. Her research interests include pharmacology, drug delivery systems, and herbal medicine. (email: andiulfianautari@unimerz.ac.id).

References

L. Pangaribuan, “Efek Samping Kosmetik Dan Penangananya Bagi Kaum Perempuan,” Jurnal Keluarga Sehat Sejahtera, vol. 15, no. 2, pp. 20–28, 2017, doi: 10.24114/jkss.v15i2.8771.

I. S. Nur alam, Henny, “Jurnal Sistem Informasi Dan Teknik Komputer,” Jurnal sistem informasi dan teknik komputer, vol. 6, p. 1, 2021.

T. H. Sinta Murlistyarini, Suci Prawitasari, Lita Setyowatie, Herwinda Brahmanti, Anggun Putri Yuniaswan, Dhany Prafita Ekasari, Dhelya Widasmara, Arif Widiatmoko, Tantari SHW, Aunur Rofiq, Santosa Basuki, Intisari Ilmu Kesehatan Kulit dan Kelamin, 1st ed. Malang: UB Press, 2018.

N. S. S. A. Riezqa Nur Attazqiah, “STUDI LITERATUR: PEMANFAATAN EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) UNTUK PERAWATAN KULIT WAJAH,” -, vol., no., pp. 1–10, 2021.

H. P. Maliangkay, R. Rumondor, D. Mario Walean, P. Studi Farmasi, and S. Tinggi Ilmu Kesehatan Trinita Manado, “Uji Efektifitas Antidiabetes Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana L) Pada Tikus Putih (Rattus Norvegicus) Yang Diinduksi Aloksan,” Chem. Prog, vol. 11, no. 1, p. 15, 2018, doi: 10.35799/cp.11.1.2018.27610.

N. Hidayah and N. Saputri, “Ekstrak Kulit Buah Manggis Sebagai Sediaan Kosmetik Cleansing Water Untuk Kulit Wajah,” pp. 16–30, 2021.

Imrawati, S. Mus, S. A. Gani, and K. I. Bubua, “Antioxidant Activity of Ethyl Acetate Fraction of Muntingia calabura L. Leaves,” Journal of Pharmaceutical and Medicinal Sciences, vol. 2, no. 2, pp. 59–62, 2017.

Fitriyanti Jumaetri sami & Sitti Rahimah, “Uji Antioksidan Ekstrak Metanol Bunga Brokoli (Brassica Oleracea Ll. Var. Italica) Dengan Metode DPPH (2,2 Diphenyl-1-Picrylhydrazyl) Dan Metode ABTS (2,2 Azinobis (3-Etilbenzotiazolin)-6-Asam Sulfonate).,” vol. 2, no. 2, pp. 107–110.

O. Apristasari, S. H. Yuliyani, D. Rahmanto, and Y. Srifiana, “FAMIKU (Face Mist-Ku) yang Memanfaatkan Ekstrak Kubis Ungu dan Bengkuang sebagai Antioksidan dan Pelembab Wajah,” Farmasains, vol. 5, no. 2, pp. 35–40, 2018.

F. Setiawan, O. Yunita, and A. Kurniawan, “Uji aktivitas antioksidan ekstrak etanol kayu secang dan FRAP,” Media Pharmaceutica Indonesiana, vol. 2, no. 2, pp. 82–89, 2018.

A. I. Dewi Sartika, Sitti Chadijah, “Analisis Antioksidan Ekstrak Etil Asetat Kulit Buah Manggis (Garcinia mangostana L.) Dengan Metode DPPH (1,1 difenil-2-pikrilhidrazil),” Jurnal Uin Alauddin, 2019.

J. Pharmascience and R. Niah, “Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Naga Merah Daerah Pelaihari , Kalimantan Selatan Dengan,” vol. 03, no. 02, pp. 36–42, 2016.

M. Dzakwan, “Formulasi Micellar Based Water Ekstrak Bunga Telang,” Parapemikir : Jurnal Ilmiah Farmasi, vol. 9, no. 2, pp. 61–67, 2020, doi: 10.30591/pjif.v9i2.2043.

Mahardika Rahmawati, Digital Digital Repository Repository Universitas Universitas Jember Jember Digital Digital Repository Repository Universitas Universitas Jember Jember. Jember: Universitas Jember, 2016.

F. Fauziah, R. Marwarni, and A. Adriani, “FORMULASI DAN UJI SIFAT FISIK MASKER ANTIJERAWAT DARI EKSTRAK SABUT KELAPA ( Cocos nucifera L),” Jurnal Riset Kefarmasian Indonesia, vol. 2, no. 1, pp. 42–51, 2020, doi: 10.33759/jrki.v2i1.74.

T. Andini, Y. Yusriadi, and Y. Yuliet, “Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai Antioksidan,” Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), vol. 3, no. 2, pp. 165–173, 2017, doi: 10.22487/j24428744.0.v0.i0.8773.

F. Handayani, H. Warnida, and S. J. Nur, “Formulasi dan Uji Aktivitas Antibakteri Streptococcus mutans dari Sediaan Mouthwash Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.),” Media Sains, vol. 9, no. April, pp. 74–84, 2016.

B. Iskandar, N. Frimayanti, F. Firmansya, T. T. Agustini, and D. D. Putri, “Evaluasi Sifat Fisik dan Uji Kelembaban Sediaan Losion Yang Dijual Secara Online-Shop,” Jurnal Dunia Farmasi, vol. 4, no. 1, pp. 8–16, 2019, doi: 10.33085/jdf.v4i1.4561.