Exploring the Potent Anti-Hyperglycemic Properties of Red Betel Leaf Ethanol Extract Fraction on Male Wistar Rats

Andi Ulfiana Utari Upi; Ahmad Irsyad Aliah; Hasniah; Nasrawati Basir; Sriyanty Sadsyam

doi:10.56741/hesmed.v2i03.267

Authors

Andi Ulfiana Utari Upi
andiulfianautari@gmail.com
Universitas Megarezky
Ahmad Irsyad Aliah Universitas Megarezky
Hasniah Universitas Megarezky
Nasrawati Basir Universitas Megarezky
Sriyanty Sadsyam Universitas Megarezky

DOI:

https://doi.org/10.56741/hesmed.v2i03.267

Keywords:

Anti-Hyperglycemic, Ethanol, Extract Fraction, Red Betel Leaf, Wistar Rats

Abstract

Hyperglycemia is characterized by an increase in blood glucose levels exceeding 200 mg/dL, an initial symptom of diabetes mellitus. Hyperglycemia can be addressed through traditional treatment with Red Betel Leaf. Red betel leaf contains phytochemical compounds, including flavonoids. Flavonoid compounds in red betel leaves possess antioxidant properties. These antioxidants can scavenge hydroxyl radicals that damage the β cells of the pancreas, thereby maximizing insulin production. Empirically, the flavonoid content in red betel leaves has been shown to lower blood glucose levels and cure diabetes mellitus. An effectiveness test of the anti-hyperglycemic properties of the ethanol extract fraction of red betel leaf was conducted. This research aimed to determine the effectiveness of the ethanol extract fraction of red betel leaf on male white rats. The method employed in this study was laboratory experimentation. Fifteen rats were divided into five treatment groups: Group I, healthy control without treatment; Group II, negative control with Na.CMC administration; Group III, positive control with glibenclamide administration; Group IV, the polar group with polar extract suspension of red betel leaf administration; Group V, the nonpolar group with nonpolar extract suspension of red betel leaf administration. In conclusion, administering the polar fraction was more effective in reducing blood glucose levels than the nonpolar fraction.

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Author Biographies

Andi Ulfiana Utari Upi, Universitas Megarezky

is a lecturer in the Pharmacy Department at the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She obtained her bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her master's degree from Universitas Hasanuddin Makassar, Indonesia. Her research interests include pharmacology, drug delivery systems, and herbal medicine. (email: andiulfianautari@unimerz.ac.id).

Ahmad Irsyad Aliah, Universitas Megarezky

is a lecturer in the Pharmacy Department at the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. He obtained her bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her master's degree from Institute Teknologi Bandung, Indonesia. With her expertise in pharmacy, she is committed to promoting excellence in education and research in the field of pharmacy. (email: ahmadirsyadaliah@unimerz.ac.id).

Hasniah, Universitas Megarezky

is a pharmacy student, Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She obtained her bachelor's degree from Megarezky University Makassar. Her research interests include pharmacology, drug delivery systems, and herbal medicine (email: nhiafai@gmail.com).

Nasrawati Basir, Universitas Megarezky

is a lecturer at the Pharmacy Department, Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She earned her Bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her Master's degree from Universitas Hasanuddin Makassar, Indonesia. With her expertise in pharmacy, she is committed to promoting excellence in education and research in the field of pharmacy. (email: nasrawatibasir@unimerz.ac.id).

Sriyanty Sadsyam, Universitas Megarezky

is an educational scientist and a lecturer in the Pharmacy Study Program at the Faculty of Pharmacy, Megarezky University Makassar, Indonesia. She earned her Bachelor's degree from Universitas Islam Negeri Alauddin Makassar and her Master's degree from Universitas Hasanuddin, Indonesia. Her research interests lie in post-incidence therapy, and she is active in various professional associations. (email: sriyantisadsyam@unimerz.ac.id).

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