An Overview of Antibiotic Solubility Based on Reconstitution Time

R. Meitha Roosmeilany; Uun Sumardi; Epa Supiani; Sitti Syabariyah; Endah Yuliany Rahmawati

doi:10.56741/hesmed.v4i01.739

Authors

R. Meitha Roosmeilany
meitharoosmeilany@gmail.com
Hasan Sadikin Hospital
Uun Sumardi Hasan Sadikin Hospital
Epa Supiani Hasan Sadikin Hospital
Sitti Syabariyah Universitas Aisyiyah Bandung https://orcid.org/0000-0002-6473-7437
Endah Yuliany Rahmawati Universitas Aisyiyah Bandung

DOI:

https://doi.org/10.56741/hesmed.v4i01.739

Keywords:

Antibiotics, Antibiotic Solubility, Drug Reconstitution, Nursing

Abstract

The reconstitution of parenteral antibiotics is the process of mixing antibiotic drugs with sterile solutions for intravenous use. According to Indonesian Nursing Law No. 38 of 2014, Article 33, nurses are authorized to provide limited pharmaceutical services, including assisting in drug reconstitution. Errors in the mixing process can lead to incorrect drug dosages or reduced efficacy. This study aims to describe the solubility of antibiotics based on the reconstitution time of antibiotics in the Medical Intermediate Care (MIC) unit at Dr. Hasan Sadikin General Hospital in Bandung. The research method used is quantitative descriptive correlational, utilizing frequency distribution to assess respondent characteristics, the antibiotics used, and their solubility. Central tendency measures are used to determine the mean solubility of antibiotics based on reconstitution time. A total of 66 samples were collected using accidental sampling techniques. The reconstitution procedure used aquabidest (distilled water) and NaCl. The duration of the reconstitution process affected the solubility of the antibiotics. It was concluded that the reconstitution and mixing procedures for parenteral preparations in the MIC unit did not fully meet Good Preparation standards. Antibiotics such as Cefepime, Vancomycin, Cefotaxime, and Meropenem had relatively longer reconstitution times compared to other antibiotics. Nurses should have the knowledge and skills to perform drug reconstitution according to standards. Hospitals should establish drug reconstitution standards to ensure the quality of medications administered to patients, thus preventing an increase in antibiotic resistance.

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Author Biographies

R. Meitha Roosmeilany, Hasan Sadikin Hospital

is a dedicated Nursing Staff member at the Directorate of Medical-Nursing and Hospital Support, Hasan Sadikin Hospital, Bandung, Indonesia. She specializes in critical care nursing and has extensive experience in patient care, particularly in high-risk and intensive care units. Her professional expertise includes healthcare quality improvement and patient safety. As a Critical Care Nursing Practitioner, she actively contributes to developing and implementing best practices in hospital settings. She is passionate about nursing education and mentorship. (email: meitharoosmeilany@gmail.com).

Uun Sumardi, Hasan Sadikin Hospital

is a specialist in internal medicine and a staff member at the Department of Internal Medicine, Hasan Sadikin Hospital, Bandung, Indonesia. With extensive experience in patient care and medical research, he focuses on internal diseases, infectious diseases, and tropical medicine. His clinical practice involves diagnosing and treating complex medical conditions, contributing to improving healthcare services. In addition to his hospital work, he is actively involved in medical education and training for healthcare professionals. He is committed to advancing medical knowledge and patient-centered care. (email: nsumardi756@gmail.com).

Epa Supiani, Hasan Sadikin Hospital

is a clinical nurse specializing in critical care at Hasan Sadikin Hospital, Bandung, Indonesia. She has years of experience in intensive care settings and is skilled in managing critically ill patients, handling emergency interventions, and providing comprehensive nursing care. She is passionate about improving patient outcomes through evidence-based nursing practices. As a dedicated healthcare professional, she actively participates in training programs and workshops to enhance her knowledge and expertise. Epa is committed to ensuring high-quality patient care and safety. (email: epasupiani84@gmail.com).

Sitti Syabariyah, Universitas Aisyiyah Bandung

is a senior lecturer and professor at the Faculty of Health Sciences, Universitas ‘Aisyiyah Bandung, Indonesia. She obtained her doctoral degree from the University of Indonesia and has extensive expertise in nursing, health, hospital management, and risk management. She has published numerous articles in international journals and serves as a reviewer for the Journal of Health Sciences and Medical Development. In addition to her academic role, she is a visiting senior lecturer at Universiti Teknologi MARA (UiTM), Malaysia. Her research interests focus on healthcare quality and patient safety. (email: sittisyabariyah@unisa-bandung.ac.id).

Endah Yuliany Rahmawati, Universitas Aisyiyah Bandung

is a lecturer in the Department of Medical-Surgical Nursing, Faculty of Health Sciences, Universitas ‘Aisyiyah Bandung, Indonesia. She specializes in medical-surgical nursing, focusing on patient care, nursing education, and clinical skills development. Her academic work includes research in evidence-based nursing practices and the enhancement of nursing education. She is committed to mentoring future nurses and improving healthcare through teaching and research. With a passion for patient-centered care, she actively participates in professional development initiatives. (email: endah.yuliany@unisa-bandung.ac.id).

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