The Relationship between the Albumin-Bilirubin Ratio and Frailty in Patients with Liver Cirrhosis

Triyanta Yuli Pramana; Alwidya Rosyid Akhmad Permana; Fatichati Budiningsih; Hanung Prasetya

doi:10.56741/IISTR.jphs.001311

Authors

Triyanta Yuli Pramana
typramana@gmail.com
Universitas Sebelas Maret https://orcid.org/0000-0001-7764-649X
Alwidya Rosyid Akhmad Permana Universitas Sebelas Maret https://orcid.org/0009-0008-9712-8719
Fatichati Budiningsih Universitas Sebelas Maret https://orcid.org/0009-0003-3398-3728
Hanung Prasetya Politeknik Kesehatan Kementrian Kesehatan Surakarta https://orcid.org/0000-0002-9728-7559

Keywords:

ALBI Score, Albumin, Bilirubin, Frailty, Liver Cirrhosis Patients

Abstract

Patients with liver cirrhosis are at risk of impaired liver function, characterized by disturbances in albumin synthesis and bilirubin secretion. The Albumin-Bilirubin (ALBI) score has been reported to be associated with the prognosis of liver cirrhosis patients. This study aimed to analyze the relationship between the ALBI score and frailty in patients with liver cirrhosis. A cross-sectional study was conducted at Dr. Moewardi General Hospital from May to September 2024. A total of 68 patients with liver cirrhosis were included. The dependent variable was frailty, while the independent variable was the ALBI score. Data were collected via a questionnaire and laboratory results, and analyzed using logistic regression. This study found a significant association between a higher ALBI score and frailty in patients with liver cirrhosis. After correcting for data entry errors, the re-analyzed data showed a significant association. A one-unit increase in the ALBI score was associated with a significant increase in the odds of frailty (OR = 13.32; 95% CI = 1.31 to 135.48; p = 0.029). These findings suggest a significant relationship between the ALBI score and frailty in patients with liver cirrhosis, indicating that patients with more severe liver dysfunction (reflected by a higher ALBI score) are more likely to be frail.

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Author Biographies

Triyanta Yuli Pramana, Universitas Sebelas Maret

is a medical professional and researcher affiliated with the Gastroenterohepatology Division of Internal Medicine at Universitas Sebelas Maret, Indonesia. His academic interests focus on gastroenterology, hepatology, internal medicine, and clinical research development. He has actively contributed to scientific publications and interdisciplinary healthcare studies. In addition to academic activities, he is involved in medical education and collaborative research initiatives aimed at improving healthcare quality and evidence-based clinical practice in Indonesia. (email: typramana@gmail.com).

Alwidya Rosyid Akhmad Permana, Universitas Sebelas Maret

is affiliated with the Faculty of Medicine, Universitas Sebelas Maret, Indonesia, specializing in Internal Medicine. His academic and professional interests include clinical medicine, patient-centered healthcare, and medical research. He has participated in various collaborative studies related to disease management and healthcare innovation. Through his involvement in academic and clinical settings, he contributes to advancing medical knowledge and supports integrating evidence-based approaches into healthcare services and medical education. (email: alwidyarosyid@gmail.com).

Fatichati Budiningsih, Universitas Sebelas Maret

is a lecturer and researcher in the Geriatric Division of Internal Medicine at Universitas Sebelas Maret, Indonesia. Her expertise centers on geriatric medicine, elderly healthcare management, and chronic disease prevention among aging populations. She has been actively engaged in academic research, community health programs, and interdisciplinary collaborations addressing elderly wellbeing. Her scholarly contributions emphasize improving the quality of life for older adults through comprehensive healthcare approaches, preventive strategies, and evidence-based geriatric medical services in Indonesia. (email: fbudiningsih1972@gmail.com).

Hanung Prasetya, Politeknik Kesehatan Kementrian Kesehatan Surakarta

is affiliated with the Study Program in Acupuncture at Politeknik Kesehatan Kementrian Kesehatan Surakarta, Surakarta, Indonesia. His academic interests include acupuncture therapy, complementary medicine, public health, and integrative healthcare practices. He has contributed to research and educational activities related to alternative and traditional medical approaches. Through academic collaboration and professional engagement, he supports the development of evidence-based complementary medicine and promotes innovative healthcare practices within Indonesia’s medical and health education sectors. (email: hanungprasetya168@gmail.com).

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